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Design and Analysis of Quality of Life Studies in Clinical Trials

By: (Author) Diane L. Fairclough

Manufacture on Demand

Ksh 26,100.00

Format: Hardback or Cased Book

ISBN-10: 1420061178

ISBN-13: 9781420061178

Edition Number: 2

Series: Chapman & Hall/CRC Interdisciplinary Statistics

Publisher: Taylor & Francis Ltd

Imprint: Chapman & Hall/CRC

Country of Manufacture: GB

Country of Publication: GB

Publication Date: Jan 7th, 2010

Print length: 424 Pages

Weight: 750 grams

Dimensions (height x width x thickness): 24.20 x 15.60 x 2.80 cms

Product Classification: Clinical trials

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Presents a range of solutions to analytic issues. This title reflects developments in methodology with coverage of mixture models and a dataset example. It implements examples using SAS and R code and incorporates a number of examples from real QoL clinical trials to illustrate design and analysis methods.

Design Principles and Analysis Techniques for HRQoL Clinical Trials
SAS, R, and SPSS examples realistically show how to implement methods

Focusing on longitudinal studies, Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition addresses design and analysis aspects in enough detail so that readers can apply statistical methods, such as mixed effect models, to their own studies. The author illustrates the implementation of the methods using the statistical software packages SAS, SPSS, and R.

New to the Second Edition

  • Data sets available for download online, allowing readers to replicate the analyses presented in the text
  • New chapter on testing models that involve moderation and mediation
  • Revised discussions of multiple comparisons procedures that focus on the integration of health-related quality of life (HRQoL) outcomes with other study outcomes using gatekeeper strategies
  • Recent methodological developments for the analysis of trials with missing data
  • New chapter on quality adjusted life-years (QALYs) and QTWiST specific to clinical trials
  • Additional examples of the implementation of basic models and other selected applications in R and SPSS

This edition continues to provide practical information for researchers directly involved in the design and analysis of HRQoL studies as well as for those who evaluate the design and interpret the results of HRQoL research. By following the examples in the book, readers will be able to apply the steps to their own trials.

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