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By: (Author) Kathleen Laura Hefferon
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Designed as a basic multidisciplinary reference for researchers, this book discusses plant transformation techniques, generation of transgenic plants, engineering of plant viruses to produce vaccine proteins or peptides, risk analysis, and future applications. It addresses the basis of mucosal immunity using plant-based oral vaccines, organelle targeting for vaccine production, and the role of glycosylation in plant-made mammalian proteins. It also considers vaccine production in entire crops or in large batch cell suspension cultures as well as the construction of clinical trials.
Transgenic plants present enormous potential to become one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary, and agricultural uses. Over the past decade, much progress has been made with respect to the development of vaccines, antibodies, and other therapeutic proteins. Biopharmaceuticals in Plants: Toward the Next Century of Medicine provides a comprehensive survey of all major aspects of the development and production of plant-made biopharmaceuticals.
Accompanied by an exhaustive list of references to facilitate further study, this critical volume:
The book concludes with a discussion of the future of plant-based vaccines and other therapeutic proteins with respect to commercial viability and as a tool to improve global public health. Far-reaching in its scope, this text is a baseline reference that students and researchers in a broad range of fields such as medicine, plant science, biotechnology, crop science, natural products chemistry, and engineering will consult regularly. It will also serve as a useful tool for individuals and companies seeking to invest in this dynamic area.
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